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***型乙酰***受体
Acetylcholine Nicotinic Receptors
Nicotinic receptors (nAChRs) are ligand-gated ion channels that modulate cell membrane potentials. Each receptor is composed of pentameric combinati*** of subunits (α1-10, β1-4, δ, ε and γ). Nicotinic receptors are generally divided into three functional classes: muscle subunits (α1, β1, δ, ε, γ), standard neuronal subunits (α1-6 and β2-4) that form in pairwise αβ combinati***, and subunits (α7-9) that can form homomeric nAChRs. Neuronal nicotinic receptors are found in the central nervous system and in autonomic ganglia where they regulate processes such as tran***itter release, cell excitability and neuronal integration. Nicotinic receptors located at the neuromuscular juncti*** of somatic muscles are resp***ible for muscular contraction.

Nicotinic (α4β2) Receptor Products

3549     3-Bromocytisine
    Potent agonist of α4β4, α4β2 and α7 nACh receptors
1518     5-Iodo-A-85380 dihydrochloride
    High affinity α4β2 and α6β2 subtype-selective agonist
1527     5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative
    Precursor to 5-Iodo-A-85380 (Cat. No. 1518)
3546     (-)-Nicotine ditartrate
    α4β2 agonist
1053       RJR 2403 oxalate
    α4β2 selective nicotinic agonist
2737      TC 2559 difumarate
    Selective partial agonist at α4β2 receptors
3754     Varenicline tartrate
    Orally active, subtype-selective α4β2 partial agonist

Antagonists
2349     Dihydro-β-erythroidine hydrobromide
    Antagonist for neuronal α4-containing nicotinic receptors
2241     DMAB-anabaseine dihydrochloride
    Antagonist at α4β2 receptors and partial agonist at α7-containing neuronal nicotinic receptors

Modulators
3328     Desformylflustrabromine hydrochloride
    Positive allosteric modulator of α4β2
4141     LY 2087101
    Potentiator of α4β2 nAChRs
Other
4125     3-pyr-Cytisine
    High affinity, partial agonist of α4β2 receptors
2736     Sazetidine A dihydrochloride
    α4β2 receptor ligand; may act as an agonist or a desensitizer


Nicotinic (α7) Receptor Products
Agonists
3549     3-Bromocytisine
    Potent agonist of α4β4, α4β2 and α7 nACh receptors
2241     DMAB-anabaseine dihydrochloride
    Partial agonist at α7-containing receptors and antagonist at α4β2 neuronal nicotinic receptors
3092     PHA 543613 hydrochloride
    Potent and selective α7 nAChR agonist
3134     PHA 568487
    α7-selective agonist
2303     PNU 282987
    Selective α7 nAChR agonist
3518     S 24795
    Partial agonist at α7 nAChR
2518     TC 1698 dihydrochloride
    α7-selective agonist

Antagonists
2133     α-Bungarotoxin
    α7 subtype-selective nAChR antagonist
3405     COG 133
    apoE peptide fragment; α7 nAChR antagonist
3119     α-Conotoxin     ImI
    α7 and α9 selective nAChR antagonist
1029     Methyllycaconitine citrate
    α7 neuronal nicotinic receptor antagonist
1356     MG 624
    α7 neuronal nicotinic receptor antagonist

Modulators
3837     CCMI
    Positive allosteric modulator of α7 nAChR
1260     Ivermectin
    Allosteric modulator of α7 nicotinic receptors
4141     LY 2087101
    Potentiator of α7 nAChRs
2995     NS 1738
    Positive allosteric modulator of α7 nAChR; active in vivo
2498     PNU 120596
    Positive allosteric modulator of α7 nAChR; active in vivo
4233     TQS
    Positive allosteric modulator of α7 nAChRs

Other
3091     FR 236924
    Enhances α7 nAChR activity; PKCε activator
Purity: >99 %    10mg

Nicotinic Receptor (Non-Selective) Products
Agonists
2809     Acetylcholine chloride
    Endogenous neurotran***itter
0352     4-Acetyl-1,1-dimethylpiperazinium iodide
    Nicotinic agonist
0351     1-Acetyl-4-methylpiperazine hydrochloride
    Nicotinic agonist
1971     (+)-Anabasine hydrochloride
    Neuronal nicotinic receptor agonist
0789     (&plu***n;)-Anatoxin A fumarate
    Nicotinic agonist
3549     3-Bromocytisine
    Potent agonist of α4β4, α4β2 and α7 nACh receptors
2810     Carbamoylcholine chloride
    Cholinergic receptor agonist
3110     (-)-Cotinine
    Major metabolite of nicotine
1390     (-)-Cytisine
    Potent, selective neuronal nicotinic agonist
0684    (&plu***n;)-Epibatidine
    Very potent nicotinic agonist
1077    (-)-Lobeline hydrochloride
    Nicotinic agonist
1271     RJR 2429 dihydrochloride
    Nicotinic receptor agonist

Antagonists
0424     Benzoquinonium dibromide
    Nicotinic antagonist
2722     Catestatin
    Non-competitive nicotinic cholinergic antagonist
1001     Chlorisondamine diiodide
    Nicotinic antagonist; slow offset
2843     Mecamylamine hydrochloride
    Non-competitive nicotinic receptor antagonist
0693     Pancuronium dibromide
    Nicotinic (neuromuscular) antagonist
2785     *** hydrochloride
    Nicotinic receptor antagonist
2438     TMPH hydrochloride
    Neuronal nicotinic receptor antagonist
2820    (+)-Tubocurarine chloride pentahydrate
    Nicotinic receptor antagonist

Blockers
4111    Hexamethonium bromide
    Nicotinic receptor blocker


Nicotinic Receptor (Other Subtype) Products
Agonists
3549     3-Bromocytisine
    Potent agonist of α4β4, α4β2 and α7 nACh receptors
1518     5-Iodo-A-85380 dihydrochloride
    High affinity α4β2 and α6β2 subtype-selective agonist
1527     5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative
    Precursor to 5-Iodo-A-85380 (Cat. No. 1518)
1348     UB 165 fumarate
    Subunit selective nAChR agonist
Antagonists
3205     ACV 1
    α9α10-selective antagonist
3120     α-Conotoxin AuIB
    Selective α3β4 nAChR antagonist
3124     α-Conotoxin EI
    α1β1δγ selective nAChR antagonist
3119     α-Conotoxin ImI
    α7 and α9 selective nAChR antagonist
1340     α-Conotoxin MII
    Potent α3β2 and β3 subunit selective nicotinic antagonist
3121     α-Conotoxin PIA
    Selective antagonist of α6-containing nicotinic receptors
3123     α-Conotoxin PnIA
    Selective α3β2 nAChR antagonist
2349     Dihydro-β-erythroidine hydrobromide
    Antagonist for neuronal α4-containing nicotinic receptors
Modulators
4141     LY 2087101
    Potentiator of nAChRs